One measure of impact is the number of innovations progressing towards the market as well as those already on the market and impacting lives. For therapeutics, diagnostics and devices, the pipeline of innovations in various stages of clinical approval illustrates the breadth and depth of University of Michigan innovation.

Clinical Drug Pipeline

These drugs were created by faculty at the University of Michigan. There are many in different stages with several already in the market.

Company IND Phase I Phase II Phase III FDA Approval Product on Market Condition/Market 
Ascentage  APG-1387           IAP Inhibitor for Anti-Cancer 
Astellas         2003 Amevive Plaque Psoriasis 
Avid Radiopharmaceuticals   AV – 133 (Diabetes) AV – 133 (Parkinsons) AV – 133 (Primary Parkinsonism)     Diabetes Type 1, PET imaging for Parkinson’s and Alzheimer’s Disease 
Baxalta   BAX930
       Thrombotic Thrombocytopenic Purpura (TTP) 
Cardiavent   CARD – 024         Spontaneous Hypertension and Heart Failure 
Cellectar   I – CLR1404         Solid Tumors 
Conatus Pharmaceuticals     IDN – 6556
     Hepatitis, Acute Liver Failure, Diabetes 
Debiopharma     Debio-1143       Head & Neck Cancer 
Dompe     Reparixin       HER2 Negative Metastatic Breast Cancer 
Etubics Corporation     AD5 CEA Vaccine       Colon, Lung, Breast Cancer 
Genzyme         2014 Cerdelga Gaucher’s Disease, Type I 
GSK (Corixa)         2003 Bexxar CD20 Positive Follicular Non-Hodgkin’s Lymphoma 
InflaRx     1-FX1       Sepsis 
Insys Therapeutics   IL13-PE38 IL13-PE38 (Gliobastoma)       Pulmonary Fibrosis; Asthma 
Lycera   LYC-30937         Inflammatory Bowel Disease 
MedImmune, Inc.       FluMist Bivalent Vaccine 2003 FluMist Influenza Vaccine 
Millendo   ATR-101         Adrenocortical Carcinoma 
NanoBio Corp   NB-1008; Fluzone IN         Seasonal Vaccine for Influenza Strain 
OncoMed Pharma   OMP – 18R5
OMP – 52M51
OMP – 52F28
OMP – 21M18 
Demicizumab (in combination w/ other drugs) OMP – 595R       Solid Tumors, Pancreatic Cancer 
RepliGen Corp (BMS)         2005 Orencia Rheumatoid Arthritis 
Sanofi   SAR405838         Neoplasm Malignant Solid Tumors 
Taxus Cardium Pharmaceuticals     GAM-501 “Excellarate”       Diabetic Foot Ulcers 
U-Michigan     Amlexanox       Type 2 Diabetes / Non-Alcoholic Fatty Liver Disease (NAFLD 
Shire     Maribavir
     Cytomegalovirus (CMV); Liver Transplant; HIV Related Eye Infections 
ThermoFisher Scientific     Xcellerated T Cells       Non-Hodgkin’s Lymphoma 

Diagnostic Pipeline

How we diagnose disease and conditions evolves as technology evolves. A number of the tests and tools used in healthcare today have been created here at the University of Michigan.

Company Preclinical CLIA 510K PMA Product on Market Condition/Market 
Arctic DX         Macula Risk Macular Degeneration 
Armune   Apifiny       Tumor Specific Non-PSA Blood Test for Prostate Cancer 
Athena Diagnostics         Atlastin (SPG3A) DNA Sequencing Test (#531), Complete Hereditary Spastic Paraplegia Evaluation (#650), Autosomal Dominant HSP Evaluation (#651) Autosomal Dominant Hereditary Spastic Paraplegia 
Athena Diagnostics         NIPA1 (SPG6) DNA Sequencing Test (#532), Complete Hereditary Spastic Paraplegia Evaluation (#650), Autosomal Dominant HSP Evaluation (#651) 
Athena Diagnostics         MR-1 (PNKD) DNA Sequencing Test (#617) Paroxysmal Nonkinesignenic Dyskinesia 
Athena Diagnostics         FIG4 DNA Sequencing Test (#224), Partial CMT Evaluation – Recessive Only (#409), Complete CMT Evaluation (#723) 
Athena Diagnostics         FIG4 DNA Sequencing Test (#224), Complete ALS Evaluation (#704) Amyotrophic Lateral Sclerosis 
Becton Dickinson HandyLab         Microfluidic Diagnostic System *BD MAX™ Nucleic acid and protein diagnostic 
GenomeDX PCATS       Decipher™ Prostate Cancer 
Hologic   TMPRSS2 Gene Fusions       Prostate Cancer 
Janssen Diagnostics       CTC-Endocrine Index COMETI P2   Metastatic Breast Cancer 
Multiple Non Exclusive Licenses         Delta 508 Mutation Cystic Fibrosis 
Novelos (Cellectar)     I-131NM404 / I124NM404     Pet Imaging Agent for Non-Small Cell Lung Cancer and other Solid Tumors 
Ventana     ERG IVD     Prostate Cancer 
ViraCor IBT         Reg3alpha, ST2 biomarkers Graft Versus Host Disease (GVHD) 

Device Pipeline

These medical devices were created to help improve medical care and everyday life. We’re tracking their progress as they make their way to the patient.

Company Prototype Safety/ Efficacy Trial(s) 501(k) / PMA Application FDA Approval Product on Market Condition on Market 
Abbott Medical Optics (IntraLase)       2002 IntrLase FS Laser LASIK eye surgery 
Great Batch Probes         Neuromodulation 
Histosonics   VortxRx®       Benign Prostate Hyperplasia 
Imbio       2014 Lung Density Analysis COPD Analysis 
Invia       2001 4D MSPECT Processing and diagnostic display of reconstructed cardiac emission 
Medtronic (Ablation Frontiers)         Pulmonary Vein Ablation Catheter (PVAC); Multi-channel Radiofrequency Generator GENius Paroxysmal Atrial Fibrilation (PAF) 
Securus Medical   Esophageal Temperature Mapping       Cardiac and Tumor Tissue Ablation 
Tissue Regeneration System (TRS)       2013 Cranial Bone Filler Skeletal Reconstruction / Bone Regeneration Technology